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Your Cancer Story Is Unique. Your Care Should Be Too.

Understanding Your Cancer Starts Here.

From tumour biopsy to liquid biopsy - OncoHelix offers a wide range of cancer genomic profiling panels catered to your needs.

Requisition Form

Your Treatment Starts With Knowing More

Our Comprehensive Genomic Profiling Panels

Aid in Cancer Diagnosis

Help in Cancer Risk Classification

Identify Targeted Therapies

Explore Our Panels

  • Uses Roche AVENIO Tumor tissue CGP Kit powered by FoundationOne Analysis Platform

    The OncoHelix-1 test offers the most in-depth insights into cancer genomics. The panel provides an extensive exploration of the tumor genome, identifying a broad range of alterations including SNVs, CNVs, Indels, and fusions. The panel matches patients with FDA-approved therapies, offers insights into resistance mechanisms, and evaluates markers like tumor mutational burden and microsatellite instability, enhancing immunotherapy decisions.

  • Uses the Illumina TST-170 Panel

    The OncoHelix-2 (DNA+RNA) test is an advanced genomic profiling test. This CGP panel offers the flexibility of detecting genetic alterations in both DNA and RNA of a range of solid tumors. It identifies actionable mutations, aiding personalized cancer therapy. The panel assists in matching patients with targeted treatments, and provides insights into potential drug resistance, and prognostication.

  • Uses the Illumina TSO-500 Panel

    The OncoHelix-3 CGP panel offers the flexibility of detecting genetic alterations in both DNA and RNA of a range of solid tumors aligned with key clinical guidelines, spanning 523 genes and including targets implicated in more than 1,600 active clinical trials. The assay also enables immuno-oncology insights through integrated tumour mutational burden (TMB) and microsatellite instability (MSI) assessment. Homologous recombination deficiency (HRD) analysis is included, providingBRCA1/2 variant detection and a genomic instability score (GIS).

  • Uses the MSK-Access ctDNA Panel Powered by SOPHiA DDM Analysis Platform

    The OncoHelix-4 is a minimally invasive liquid biopsy panel tailored for solid tumors. Serving as either an alternative or a supplementary method to tissue assays, it's especially valuable when securing tissue samples poses considerable challenges or potential risks. The panel assists in matching patients with targeted treatments, and provides insights into potential drug resistance, and prognostication.

  • Uses the SOPHiA GENETICS Myeloid Plus Panel and SOPHiA DDM Analysis Platform

    This panel offers next-generation sequencing for myeloid malignancies, identifying genetic alterations in DNA and RNA across key genes. It aids in precise diagnosis, prognosis, and therapeutic decisions for myeloid cancers. The panel supports risk stratification and monitors disease progression, providing comprehensive insights for tailored patient management

  • Uses the Avitia Find It® Panel.

    OncoHelix - Follow It panel is a high performance amplicon panel assay designed for next-generation sequencing (NGS) to detect clinically actionable genomic mutations in solid tumor biopsies. It analyzes 38 cancer-associated genes, 26 exons, and over 337 hotspots, focusing on key genetic alterations that indicate sensitivity and resistance to approved and investigational therapies, as well as diagnostic and prognostic cancer biomarkers.

  • Uses the Avitia Follow It® ctDNA Panel.

    OncoHelix - Follow It panel is an amplicon panel assay, designed for next-generation sequencing (NGS) to detect clinically actionable genomic mutations in cell-free circulating tumor DNA. It analyzes 38 cancer-associated genes, 26 exons, and over 337 hotspots, focusing on key genetic alterations that indicate sensitivity and resistance to approved and investigational therapies, as well as diagnostic and prognostic cancer biomarkers.

Compare Our Panels

Ordering a Test

Step 1 Physician To Complete the OncoHelix Genomics Requisition.

  • Patient details are filled out at the top of the requisition under “Patient Information.”
  • Physician details are completed under “Order Information.”
  • Physician indicates the patient’s type of cancer under “Diagnosis”. For example, Colorectal.
  • Physician selects type of gene panel test under “Test Request”. A detailed listing of the genes included in each panel is listed on page 3 of the requisition.

Step 2 Send the completed requisition to the OncoHelix lab by Fax to 403 210 8176.

Note: OncoHelix NGS lab and NGS testing are available at all locations across Canada, the US, and worldwide. Samples can be shipped to the OncoHelix lab for testing from anywhere, there is no geographic limitation to conduct a tissue-based and liquid-biopsy NGS test.

Step 3 OncoHelix will contact you in 3 business days.

An OncoHelix customer navigator will contact you via email within 3 business days to arrange for the test to be completed. A secure payment link will be provided for your convenience. All major credit cards are accepted. The customer navigator will also provide instructions for any further actions if required.

Step 4 Tumour Genomic Profile Report will be sent to you in 4 weeks.

The CGP test requires 4 weeks to complete: starting from the arrival time of the prepared specimen to the OncoHelix Lab in Calgary, Alberta to the final result reviewed by our team of pathologists. When the genomic test is completed, and the genomic profile is analyzed, your oncologist or ordering physician will receive an electronic report. The patient will also receive a copy of the report.

Requisition Form

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Residents of Ontario, British Columbia and Saskatchewan will need to fill this TRF in addition to the requisition above.

Panel - Gene Information

  • Small Variants (306):

    ABL1, ACVR1B, AKT1, AKT2, AKT3, ALK, ALOX12B, AMER1, APC, AR, ARAF, ARFRP1, ARID1A, ASXL1, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXL, BAP1, BARD1, BCL2, BCL2L1, BCL2L2, BCL6, BCOR, BCORL1, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTG2, BTK, C11orf30, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD22, CD274, CD70, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHEK1, CHEK2, CIC, CREBBP, CRKL, CSF1R, CSF3R, CTCF, CTNNA1, CTNNB1, CUL3, CUL4A, CXCR4, CYP17A1, DAXX, DDR1, DDR2, DIS3, DNMT3A, DOT1L, EED, EGFR, EP300, EPHA3, EPHB1, EPHB4, ERBB2, ERBB3, ERBB4, ERCC4, ERG, ERRFI1, ESR1, EZH2, FAM46C, FANCA, FANCC, FANCG, FANCL, FAS, FBXW7, FGF10, FGF12, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT3, FOXL2, FUBP1, GABRA6, GATA3, GATA4, GATA6, GID4 (C17orf39), GNA11, GNA13, GNAQ, GNAS, GRM3, GSK3B, H3F3A, HDAC1, HGF, HNF1A, HRAS, HSD3B1, ID3, IDH1, IDH2, IGF1R, IKBKE, IKZF1, INPP4B, IRF2, IRF4, IRS2, JAK1, JAK2, JAK3, JUN, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIT, KLHL6, KMT2A (MLL), KMT2D (MLL2), KRAS, LTK, LYN, MAF, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAPK1, MCL1, MDM2, MDM4, MED12, MEF2B, MEN1, MERTK, MET, MITF, MKNK1, MLH1, MPL, MRE11A, MSH2, MSH3, MSH6, MST1R, MTAP, MTOP, MUTYH, MYC, MYCL, MYCN, MYD88, NBN, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NT5C2, NTRK1, NTRK2, NTRK3, P2RY8, PALB2, PARK2, PARP1, PARP2, PARP3, PAX5, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PIK3C3B, PIK3C3G, PIK3CA, PIK3CB, PIK3R1, PIM1, PMS2, POLD1, POLE, PPARG, PPP2R1A, PPP2R2A, PRDM1, PRKAR1A, PRKCI, PTCH1, PTEN, PTPN11, PTPRO, QKI, RAC1, RAD21, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RARA, RB1, RBM10, REL, RET, RICTOR, RNF43, ROS1, RPTOR, SDHA, SDHB, SDHC, SDHD, SETD2, SF3B1, SGK1, SMAD2, SMAD4, SMARCA4, SMARCB1, SMO, SNCAIP, SOCS1, SOX2, SOX9, SPEN, SPOP, SRC, STAG2, STAT3, STK11, SYK, TBX3, TEK, TET2, TIPARP, TNFAIP3, TNFRSF14, TP53, TSC1, TSC2, TYRO3, U2AF1, VEGFA, VHL, WHSC1, WHSC1L1, WT1, XPO1, XRCC2, ZNF217, ZNF703

    DNA Fusion Target Genes (36):

    ALK, BCL2, BCR, BRAF, BRCA1, BRCA2, CD74, EGFR, ETV4, ETV5, ETV6, EWSR1, EZR, FGFR1, FGFR2, FGFR3, KIT, KMT2A (MLL), MSH2, MYB, MYC, NOTCH2, NTRK1, NTRK2, NUTM1, PDGFRA, RAF1, RARA, RET, ROS1, RSPO2, SDC4, SLC34A2, TERC, TERT, TMPRSS2

  • Specimen compatibility: Genomic DNA & RNA extracted from fresh frozen and FFPE tissues

    DNA GENES:

    Small variants and indel (148): AKT1, AKT2, AKT3, ALK, APC, AR, ARID1A, ATM, ATR, BAP1, BARD1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BRIP1, BTK, CARD11, CCND1, CCND2, CCNE1, CD79A, CD79B, CDH1, CDK12, CDK4, CDK6, CDKN2A, CEBPA, CHEK1, CHEK2, CREBBP, CSF1R, CTNNB1, DDR2, DNMT3A, EGFR, EP300, ERBB2, ERBB3, ERBB4, ERCC1, ERG, ESR1, EZH2, FAM175A, FANCI, FANCL, FBXW7, FGF1, FGF10, FGF2, FGF23, FGF3, FGF4, FGF5, FGF7, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT3, FOXL2, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, INPP4B, JAK2, JAK3, KDR, KIT, KRAS, MAP2K1, MAP2K2, MCL1, MDM2, MDM4, MET, MLH1, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCN, MYD88, NBN, NF1, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NRG1, PALB2, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PMS2, PTCH1, PTEN, PTPN11, RAD51B, RAD51C, RAD54L, RB1, RET, RICTOR, ROS1, SLX4, SMAD4, SMARCB1, SMO, STK11, TET2, TP53, TSC1, TSC2
    DNA amplification target genes (59): AKT2, ALK, AR, ATM, BRAF, BRCA1, BRCA2, CCND1, CCND3, CCNE1, CDK4, CDK6, CHEK1, CHEK2, EGFR, ERBB2, ERBB3, ERCC1, ERCC2, ESR1, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, JAK2, KIT, KRAS, LAMP1, MDM2, MDM4, MET, MYC, MYCL1, MYCN, NRAS, NRG1, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PTEN, RAF1, RET, RICTOR, RPS6KB1, TFRC

    RNA GENES:

    RNA fusion target genes (55): ABL1, AKT3, ALK, AR, AXL, BCL2, BRAF, BRCA1, BRCA2, CDK4, CSF1R, EGFR, EML4, ERBB2, ERG, ESR1, ETS1, ETV1, ETV4, ETV5, EWSR1, FGFR1, FGFR2, FGFR3, FGFR4, FLI1, FLT1, FLT3, JAK2, KDR, KIF5B, KIT, KMT2A (MLL), MET, MLLT3, MSH2, MYC, NOTCH1, NOTCH2, NOTCH3, NRG1, NTRK1, NTRK2, NTRK3, PAX3, PAX7, PDGFRA, PDGFRB, PIK3CA, PPARG, RAF1, RET, ROS1, RPS6KB1, TMPRSS2

  • Specimen compatibility: Genomic DNA & RNA extracted from fresh frozen and FFPE tissues

    DNA GENES:

    Small variants and indel, amplification target genes: ABL1, ABL2, ACVR1, ACVR1B, AKT1, AKT2, AKT3, ALK, ALOX12B, ANKRD11, ANKRD26, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, BAP1, BARD1, BBC3, BCL10, BCL2, BCL2L1, BCL2L11, BCL2L2, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTK, C11orf30, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD274, CD276, CD74, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CENPA, CHD2, CHD4, CHEK1, CHEK2, CIC, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CSNK1A1, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CUX1, CXCR4, CYLD, DAXX, DCUN1D1, DDR2, DDX41, DHX15, DICER1, DIS3, DNAJB1, DNMT1, DNMT3A, DNMT3B, DOT1L, E2F3, EED, EGFL7, EGFR, EIF1AX, EIF4A2, EIF4E, EML4, EP300, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERG, ERRFI1, ESR1, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EZH2, FAM123B, FAM175A, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FAS, FAT1, FBXW7, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLI1, FLT1, FLT3, FLT4, FOXA1, FOXL2, FOXO1, FOXP1, FRS2, FUBP1, FYN, GABRA6, GATA1, GATA2, GATA3, GATA4, GATA6, GEN1, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GPR124, GPS2, GREM1, GRIN2A, GRM3, GSK3B, H3F3A, H3F3B, H3F3C, HGF, HIST1H1C, HIST1H2BD, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST2H3D, HIST3H3, HNF1A, HNRNPK, HOXB13, HRAS, HSD3B1, HSP90AA1, ICOSLG, ID3, IDH1, IDH2, IFNGR1, IGF1, IGF1R, IGF2, IKBKE, IKZF1, IL10, IL7R, INHA, INHBA, INPP4A, INPP4B, INSR, IRF2, IRF4, IRS1, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIF5B, KIT, KLF4, KLHL6, KRAS, LAMP1, LATS1, LATS2, LMO1, LRP1B, LYN, LZTR1, MAGI2, MALT1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAP3K14, MAP3K4, MAPK1, MAPK3, MAX, MCL1, MDC1, MDM2, MDM4, MED12, MEF2B, MEN1, MET, MGA, MITF, MLH1, MLL, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MST1, MST1R, MTOR, MUTYH, MYB, MYC, MYCL1, MYCN, MYD88, MYOD1, NAB2, NBN, NCOA3, NCOR1, NEGR1, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NKX3-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NRG1, NSD1, NTRK1, NTRK2, NTRK3, NUP93, NUTM1, PAK1, PAK3, PAK7, PALB2, PARK2, PARP1, PAX3, PAX5, PAX7, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PDPK1, PGR, PHF6, PHOX2B, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLCG2, PLK2, PMAIP1, PMS1, PMS2, PNRC1, POLD1, POLE, PPARG, PPM1D, PPP2R1A, PPP2R2A, PPP6C, PRDM1, PREX2, PRKAR1A, PRKCI, PRKDC, PRSS8, PTCH1, PTEN, PTPN11, PTPRD, PTPRS, PTPRT, QKI, RAB35, RAC1, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RANBP2, RARA, RASA1, RB1, RBM10, RECQL4, REL, RET, RFWD2, RHEB, RHOA, RICTOR, RIT1, RNF43, ROS1, RPS6KA4, RPS6KB1, RPS6KB2, RPTOR, RUNX1, RUNX1T1, RYBP, SDHA, SDHAF2, SDHB, SDHC, SDHD, SETBP1, SETD2, SF3B1, SH2B3, SH2D1A, SHQ1, SLIT2, SLX4, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMARCD1, SMC1A, SMC3, SMO, SNCAIP, SOCS1, SOX10, SOX17, SOX2, SOX9, SPEN, SPOP, SPTA1, SRC, SRSF2, STAG1, STAG2, STAT3, STAT4, STAT5A, STAT5B, STK11, STK40, SUFU, SUZ12, SYK, TAF1, TBX3, TCEB1, TCF3, TCF7L2, TERC, TERTa, TET1, TET2, TFE3, TFRC, TGFBR1, TGFBR2, TMEM127, TMPRSS2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TP63, TRAF2, TRAF7, TSC1, TSC2, TSHR, U2AF1, VEGFA, VHL, VTCN1, WISP3, WT1, XIAP, XPO1, XRCC2, YAP1, YES1, ZBTB2, ZBTB7A, ZFHX3, ZNF217, ZNF703, ZRSR2


    RNA GENES:

    RNA fusion target genes (55): ABL1, AKT3, ALK, AR, AXL, BCL2, BRAF, BRCA1, BRCA2, CDK4, CSF1R, EGFR, EML4, ERBB2, ERG, ESR1, ETS1, ETV1, ETV4, ETV5, EWSR1, FGFR1, FGFR2, FGFR3, FGFR4, FLI1, FLT1, FLT3, JAK2, KDR, KIF5B, KIT, MET, MLL, MLLT3, MSH2, MYC, NOTCH1, NOTCH2, NOTCH3, NRG1, NTRK1, NTRK2, NTRK3, PAX3, PAX7, PDGFRA, PDGFRB, PIK3CA, PPARG, RAF1, RET, ROS1, RPS6KB1, TMPRSS2

  • Specimen compatibility: ctDNA and genomic DNA extracted from plasma and whole blood samples, respectively.

    Small variants and indel (144): APC, AR, ARID1A, ASXL1, ATM, BAP1, BRCA1, BRCA2, CDK12, CDK4, CDKN2A, CHEK2, DNMT3A, ERCC2, FBXW7, FOXL2, GATA3, HIST1H3B, KDM6A, KEAP1, KRAS, MLH1, MSH2, MSH6, NFI, PALB2, PMS2, PPM1D, PTCH1, PTEN, RB1, SMAD4, STK11, TET2, TP53, TSC1, TSC2, VHL, ALK, BRAF, EGFR, FGFR2, FGFR3, MET, NTRK1, RET, ROS1, ETV6, AKT1, ARAF, ARID2, B2M, BCL2, BCOR, CARD11, CBFB, CBL, CCND1, CD79B, CDH1, CIC, CREBBP, CTCF, CTNNB1, DICER1, DIS3, EIF1AX, EP300, ERBB2, ERBB3, ESR1, EZH2, FGFR1, FGFR4, FLT3, FOXA1, FOXO1, FOXP1, FUBP1, GNA11, GNAQ, GNAS, H3F3A, HRAS, IDH1, IDH2, IKZF1, INPPL1, JAK1, JAK2, KIT, KNSTRN, MAP2K1, MAP2K2, MAPK1, MAX, MED12, MSH3, MTOR, MYC, MYCN, MYD88, MYOD1, NFE2L2, NOTCH1, NPM1, NRAS, NTRK2, NTKR3, NUP93, PAK5, PDGFRA, PHF6, PIK3CA, PIK3CB, PIK3R1, PIK3R2, PIM1, POLE, POT1, PPP2R1A, PPP6C, PRKCI, PTPN11, RAC1, RAD54L, RAF1, RHOA, RIT1, RRAS2, RXRA, SETD2, SF3B1, SOS1, SPOP, SRSF2, STAT3, STK19, TCF7L2, TGFBR1, TGFBR2, TP63, U2AF1, XPO1

    DNA amplification target genes (38): APC, AR, ARID1A, ASXL1, ATM, BAP1, BRCA1, BRCA2, CDK12, CDK4, CDKN2A, CHEK2, DNMT3A, ERCC2, FBXW7, FOXL2, GATA3, HIST1H3B, KDM6A, KEAP1, KRAS, MLH1, MSH2, MSH6, NF1, PALB2, PMS2, PPM1D, PTCH1, PTEN, RB1, SMAD4, STK11, TET2, TP53, TSC1, TSC2, VHL

    DNA Fusions (10): ALK, BRAF, EGFR, FGFR2, FGFR3, MET, NTRK1, RET, ROS1, ETV6

  • Targeted RNA Fusions

    ATF7IP-JAK2; BCR-ABL1; BCR-FGFR1; BCR-JAK2; BCR-PDGFRA; BMP2K-ZNF384; CBFA2T3-GLIS2; CBFB-MYH11; CCDC6PDGFRB; CHIC2-ETV6; CNTRL-FGFR1; CREBBP-ZNF384; CUX1-FGFR1; DEK-NUP214; EBF1JAK2; EBF1-PDGFRB; EML1-ABL1; EP300-ZNF384; ETV6-ABL1; ETV6-ARNT; ETV6-JAK2; ETV6-NTRK3; ETV6-NTRK3; ETV6-PDGFRB; ETV6-RU NX1; ETV6RUNX1; FGFR1OP-FGFR1; FIP1L1-PDGFRA; FOXP1-ABL1; INPP5D-ABL1; KAT6A-CREBBP; KMT2AAFDN; KMT2A-AFF1; KMT2A-AFF3; KMT2A-AFF4; KMT2A-ARHGAP26; KMT2AARHGEF12; KMT2AARHGEF17; KMT2A-C2CD3; KMT2A-CBL; KMT2A-CIP2A; KMT2A-CREBBP; KMT2A-DCPS; KMT2A-ELL; KMT2A-EPS15; KMT2A-FOXO3; KMT2AKMT2A; KMT2A-KNL1; KMT2A-MAML2; KMT2AMAPRE1; KMT2A-MLLT1; KMT2AMLLT10; KMT2A-MLLT11; KMT2A-MLLT3; KMT2A-MLLT6; KMT2A-NRIP3; KMT2A-RARA; KMT2A-SEP5; KMT2A-SEPT6; KMT2A-SEPT9; KMT2A-SEPT9; KMT2ATET1; MEF2D-CSF1R; MN1-ETV6; MNX1-ETV6; MYB-GATA1; NCOR1-LYN; NDE1-PDGFRB; NPM1-MLF1; NPM1RARA; NUP214-ABL1; NUP98-DDX10; NUP98-HOXA9; NUP98-KDM5A; NUP98-NSD1; NUP98-RAP1GDS1; NUP98-TOP1; OFD1-JAK2; P2RY8-CRLF2; PAG1-ABL2; PAX5-ETV6; PAX5-JAK2; PAX5-ETV6; PAX5-JAK2; PCM1-JAK2; PDE4DIP-PDGFRB; PICALM-MLLT10; PML-RARA; RANBP2-ABL1; RBM15-MKL1; RCSD1-ABL1; RCSD1-ABL1; RUNX1-RUNX1T1; SET-NUP214; SFPQ-ABL1; SNX2-ABL1; SPAG9-JAK2; SPTBN1FLT3; SPTBN1-PDGFRB; SSBP2-CSF1R; SSBP2-JAK2; STAT5B-RARA; STIL-TAL1; STRN-PDGFRA; STRN3-JAK2; TAF15-ZNF384; TCF3-HLF; TCF3-PBX1; TERF2JAK2; TPM3-PDGFRB; TPR-FGFR1; TRIM24-FGFR1; ZBTB16-ABL1; ZBTB16-RARA; ZC3HAV1ABL2; ZEB2-PDGFRB; ZMIZ1-ABL1; ZMYM2-FGFR1

    DNA Targets (Exons) Coverage Details

    ABL1 (4-9); ASXL1 (10,12,13); BRAF (15); CALR (9); CBL (8,9); CEBPA (full); CSF3R (full); DNMT3A (full); ETV6 (full); EZH2 (full); FLT3 (13-15,20); HRAS (2,3); IDH1 (4); IDH2 (4); JAK2 (full); KIT (2,8-11,13,17,18); KRAS (2,3); MPL (10); NPM1 (10,11); NRAS (2,3); PTPN11 (3,7-13); RUNX1 (full); SETBP1 (4); SF3B1 (10- 16); SRSF2 (1); TET2 (full); TP53 (full); U2AF1 (2,6); WT1 (6-10); ZRSR2 (full)

  • AKT1 (E17), ALK (T1151, L1152, C1156, F1174, L1196, L1198, G1202, D1203, S1206, G1269, R1275, Y1278), AR (L702, V716, S741, W742, Q784, H875, F877, T878, M896), BRAF (Q201, G464, G466, F468, G469, Y472, D594, F595, G596, L597, V600, K601, part of Exon15 (V600-M620), G606), CTNNB1 (D32, S33, G34, I35, H36, S37, T41, S45), CCNE1 (Amplification), DDR2 (L239, I638, S768), DICER1 (D1705-D1709, G1809, D1810-E1813), EGFR (R108, A289, S492, P596, G598, Exon18 (E709, L718, G719), Exon19 (L747, A750, K754), Exon20 (S768, T790, L792, G796, C797, L798), Exon21 (L833, L838, L858, L861), Amplification), ERBB2(G309, S310, K753, L755, I767, D769, Exon20 (V773, G776, V777), Amplification), ESFR1 (K303, E380, S463, V534, P535, L536, Y537, D538), FGFR1 (N546, K656, Amplification), FGFR2 (S252, P253, W290, A315, S372, Y375, C382, N549, K659, E731, E777, Amplification), FGFR3 (R248, S249, G370, S371, Y373, G380, A391, K650), FOXL2 (C134), GNA11 (Q209), GNAQ (Q209), GNAS (R201), HRAS (G12, G13, Q61), IDH1 (R132), IDH2 (R140, R172), KIT (S476, Y553, W557, V559, V560, L576, K642, V654, T670, D816, D820, N822, Y823, A829, Exon9, Exon11, Exon13, Amplification), KRAS (K5, A11, G12, G13, L19, Q22, A59, G60, Q61, K117, A146, Amplification), MAP2K1 (F53, Q56, K57, K59, V60, D67, I103, I111, C121, N122, P124, P387), MAP2K2 (F57, Q60, K61, L119, H123, G132), MET (T1010, V1110, H1112, V1206, L1213, D1246, Y1248, Y1253, Exon13, Exon14 , Exon 14 skipping regions, Exon18, Amplification), NRAS (G12, G13, A59, G60, Q61, K117, A146), NTRK1 (F589, G595, G667), NTRK3 (G623, G696), PDGFRA (R560-E571, P577, N659, L839-Y849, D842), PIK3CA(R88, C90, R93, P104, G106, N107, R108, K111, R115, N345, R357, G364, E365, Exon6 [start to P377], C420, E453, P539, E542, E545, Q546, D549, E970, E978, M1043, N1044, A1046, H1047, G1049 Amplification), POLE (Exons 9-14 (P286R, M295R, S297F, F367S, D368Y, V411L, L424I, M444K, A456P, S459F)), PTCH1 (W844, G1093), PTEN(A126, G129, R130, R173, R233, K254-K267), RET (G533, K603, C609, C611, C618, C620, C630, D631, C634, G691, E768, L790, Y791, V804, Y806, A883, R886, S904, M918, A919, Exon10, Exon 13, Exon15), ROS1 (S1986, L2026, G2032), STK11 (Q37, P281), TP53 (Exons 2-11), MSI (21 amplicons)

  • AKT1 (E17), ALK (T1151, L1152, C1156, F1174, L1196, L1198, G1202, D1203, S1206, G1269, R1275, Y1278), AR (L702, V716, S741, W742, Q784, H875, F877, T878, M896), BRAF (Q201, G464, G466, F468, G469, Y472, D594, F595, G596, L597, V600, K601, part of Exon15 (V600-M620), G606), CTNNB1 (D32, S33, G34, I35, H36, S37, T41, S45), CCNE1 (Amplification), DDR2 (L239, I638, S768), DICER1 (D1705-D1709, G1809, D1810-E1813), EGFR (R108, A289, S492, P596, G598, Exon18 (E709, L718, G719), Exon19 (L747, A750, K754), Exon20 (S768, T790, L792, G796, C797, L798), Exon21 (L833, L838, L858, L861), Amplification), ERBB2(G309, S310, K753, L755, I767, D769, Exon20 (V773, G776, V777), Amplification), ESFR1 (K303, E380, S463, V534, P535, L536, Y537, D538), FGFR1 (N546, K656, Amplification), FGFR2 (S252, P253, W290, A315, S372, Y375, C382, N549, K659, E731, E777, Amplification), FGFR3 (R248, S249, G370, S371, Y373, G380, A391, K650), FOXL2 (C134), GNA11 (Q209), GNAQ (Q209), GNAS (R201), HRAS (G12, G13, Q61), IDH1 (R132), IDH2 (R140, R172), KIT (S476, Y553, W557, V559, V560, L576, K642, V654, T670, D816, D820, N822, Y823, A829, Exon9, Exon11, Exon13, Amplification), KRAS (K5, A11, G12, G13, L19, Q22, A59, G60, Q61, K117, A146, Amplification), MAP2K1 (F53, Q56, K57, K59, V60, D67, I103, I111, C121, N122, P124, P387), MAP2K2 (F57, Q60, K61, L119, H123, G132), MET (T1010, V1110, H1112, V1206, L1213, D1246, Y1248, Y1253, Exon13, Exon14 , Exon 14 skipping regions, Exon18, Amplification), NRAS (G12, G13, A59, G60, Q61, K117, A146), NTRK1 (F589, G595, G667), NTRK3 (G623, G696), PDGFRA (R560-E571, P577, N659, L839-Y849, D842), PIK3CA(R88, C90, R93, P104, G106, N107, R108, K111, R115, N345, R357, G364, E365, Exon6 [start to P377], C420, E453, P539, E542, E545, Q546, D549, E970, E978, M1043, N1044, A1046, H1047, G1049 Amplification), POLE (Exons 9-14 (P286R, M295R, S297F, F367S, D368Y, V411L, L424I, M444K, A456P, S459F)), PTCH1 (W844, G1093), PTEN(A126, G129, R130, R173, R233, K254-K267), RET (G533, K603, C609, C611, C618, C620, C630, D631, C634, G691, E768, L790, Y791, V804, Y806, A883, R886, S904, M918, A919, Exon10, Exon 13, Exon15), ROS1 (S1986, L2026, G2032), STK11 (Q37, P281), TP53 (Exons 2-11), MSI (21 amplicons)